Author/Authors :
Abo-Ghanema, Ismail I. Damanhour University - Faculty of Veterinary Medicine - Department of Physiology, Egypt , Elnasharty, Mohamed A. Damanhour University - Faculty of Veterinary Medicine - Department of Histology, Egypt , Sadek, Kadry M. Damanhour University - Faculty of Veterinary Medicine - Department of Biochemistry, Egypt , Abd Elrehim, Attaa M. Damanhour University - Faculty of Veterinary Medicine - Department of Physiology, Egypt
Abstract :
The present study aimed to evaluate the effect of zinc on some hematological and biochemical parameters in thioacitamide (TAA) induced liver cirrhotic rats. For this purpose 60 male Albino rats were divided into six groups (n=10). Group I, control rats (I.p.1ml saline, every other day for 8 weeks). Group II, received zinc citrate (5 mg/kg B.W., i.p, every other day for 8 weeks) .Group III, received zinc sulfate (10 mg/kg B.W., i.p , every other day for 8 weeks). Group IV, received thioacetamide (200mg/kg B.w., i.p, three times weekly for 8 weeks). Group V, received zinc citrate and thioacitamide at the same time and dose of group II and group IV for 8 weeks, Group VI, received zinc sulfate and thioacitamide at the same time and dose of group III and group IV for 8 weeks. Some blood parameter (RBCs, HGB, HCT, Platelet, WBCs) were determined by using automatic blood counter apparatus also some biochemical parameters (GPT, GOT, ALP, GGT, Total protein and Albumin) were determined in serum. Results showed that in zinc citrate and zinc sulfate treated groups there is a significant increase in RBCs, HGB and HCT values and significant decrease in WBCs while the thrombocyte values did not show any significant difference among the study groups compared with control group ( P .05).Also all blood parameters decreased in thioacitamide treated group as compared with control While zinc supplementation in combined treated groups managed to decrease the adverse effect of thioacitamide on all blood parameters . Furthermore, a significant increase in (GPT, GOT, ALP and GGT) with a significant decrease of total protein and albumin in TAA treated group. However, treatment with zinc citrate and zinc sulfate and combined treatment showed a significant decrease in (GPT, GOT, ALP and GGT) with a significant increase in total protein and albumin in groups treated with zinc citrate and zinc sulfate and also combined treated groups . Results of present study indicate that zinc have a protective effect against the thioacetamide induced liver cirrhosis.
Keywords :
Biochemical parameter , Blood parameter. , Thioacetamide , Zinc citrate , Zinc Sulfate
