Distribution of Paraoxonase-1 enzyme Activity in some Camel s Tissues

Paraoxonase-1 (PON1, aryldialkylphosphatase) is a calcium-dependent esterase enzyme synthesized in the liver and it is mainly associated with a high density lipoprotein (HDL).This study aimed to investigate the PON1 enzyme activities in male camel s serum tissues and its distribution among different tissues (liver, heart and kidney) in immature and mature camels. PON1 activity in serum (32 dromedary camels, 17one of them immature ≤ 5 years; 15 one mature 5years) were 115.89 ± 11.37 U/L and 114.43 ± 11.87 U/L, respectively. The results showed that PON1 was highly distributed in the liver then kidney and heart tissues in immature camels (2.74 ± 0.42, 1.66 ± 0.14, 0.017 ± 0.005 U/g) as well in mature camels (2.41 ± 0.29, 1.41 ± 0.12, 0.019 ± 0.005 U/g), respectively. Also, Glutathione peroxidase (GPx) and Superoxide dismutase (SOD) were highly distributed in liver then kidney and heart tissues. Moreover, GPx activity in liver was higher with increased camel s age. PON1 is correlated positively with GPx, SOD and HDL-c but negatively correlated with MDA and total cholesterol. Furthermore, was found positive correlation between total cholesterol and LDL-c in serum and hepatic tissues.