Author/Authors :
Zentina, Dace Riga East Clinical University Hospital - Department of Pulmonology, LATVIA , Zentina, Dace Rîga Stradins University - Department of Internal Diseases, LATVIA , Stukena, Inga Riga East Clinical University Hospital - Department of Pulmonology, LATVIA , Stukena, Inga Rîga Stradins University - Department of Internal Diseases, LATVIA , Grînberga, Sarma Riga East Clinical University Hospital, LATVIA , Krams, Alvils University of Latvia - Faculty of Medicine, LATVIA , Krams, Alvils Riga East Clinical University Hospital - Department of Pulmonology, LATVIA , Lejnieks, Aivars Riga East Clinical University Hospital - Department of Pulmonology, LATVIA , Lejnieks, Aivars Rîga Stradins University - Department of Internal Diseases, LATVIA
Abstract :
The significance of carbohydrate (cancer) antigen 125 (Ca-125) and carcinoembryonic antigen (CEA) tumour markers levels in differential diagnostics of malignant and benign pleural effusion was studied. Within this prospective study, 121 patients with fluids of various aetiology in the pleural cavity were analysed. Malignant pleural effusion was detected in 55 patients, parapneumonic effusion in 28 patients, transudative effusion of cardiac origin in 31 patients, pancreatitis in one patient and tuberculous pleurisy in five patients. The highest accuracy in diagnosis of malignancy was observed for Ca-125 and CEA levels in the pleural fluid: 75.2% at cut-off value ≥1452 U/mL and 76.9% at cut-off value ≥ 6.58 ng/mL, respectively. We conclude that the level of tumour markers in pleural fluid has additional diagnostic significance in the differential diagnosis of malignant and benign pleural effusions
Keywords :
pleural fluid , malignant effusion , tumour markers , CA , 125 , CEA
