ANTI PROLIFERATIVE ACTIVITIES OF 32 MALAYSIAN PLANT SPECIES IN BREAST CANCER CELL LINES

Anti-proliferative activities of 32 Malaysian plant species in breast cancer cell lines. Anti-proliferative activities of 143 crude extracts obtained from 32 plants collected from the rain forests of Pahang, Malaysia, were evaluated in two breast cancer cell lines, i.e. MCF-7 and T47D, obtained from the American Type Culture Collection, USA. The objective of this study was to bioprospect a list of plants to find out their potential to be developed into anti-cancer drug(s), by means of bioassay guided isolation procedure. After performing sulforhodamine-B assay, 13 crude extracts from 11 plant species were found to have active anti-proliferative effects (IC50≤ 100μg ml-1)