Author/Authors :
Vaseghi Maghvan, Padina Proteomics Research Center - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Jeibouei, Shabnam Department of Biotechnology - School of Advanced Technologies in Medicine - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Akbari, Mohammad Esmael Cancer Research Center - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Niazi, Vahid Department of Tissue Engineering and Applied Cell Sciences - School of Advanced Technologies in Medicine - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Karami, Farshid Department of Tissue Engineering and Applied Cell Sciences - School of Advanced Technologies in Medicine - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Rezvani, Alireza Department of Hematology - Medical Oncology and Stem Cell Transplantation - Hematology Research Center - Shiraz University of Medical Sciences - Shiraz, Iran , Ansarinejad, Nafiseh Department of Hematology and Oncology - Iran University of medical science - Tehran, Iran , Abbasinia, Masroor National Iranian South Oil Company - Ahvaz, Iran , Sarvari, Gisoo Department of Pharmaceutical Chemistry - Faculty of Pharmaceutical Chemistry - Tehran Medical Sciences - Islamic Azad University - Tehran, Iran , Zali, Hakimeh Proteomics Research Center - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Talaie, Ramin Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences - Tehran, Iran
Abstract :
Colorectal cancer (CRC) is a heterogeneous disease with various genetic and epigenetic factors leading to difficulties in response to
both the therapy and drug resistance. Moreover, even in tumors with similar histopathological characteristics, different responses and
molecular features could be observed because of the genetic basis and its interactions with the living environment. Through
personalized medicine, we can classify patients into separate groups according to their genetic and epigenetic features and their
susceptibility for a specific disease which could help with choosing the best therapeutic approach. In this review, genetic and
epigenetic factors that cause heterogeneity in colorectal cancer are evaluated and proper drug administration in both chemotherapy
and target therapy are suggested.
Keywords :
Chemotherapy , Colorectal cancer , Personalized medicine , Biomarker , Targeted therapy
