Voltammetric Determination of Famotidine Using a Bilayer of Electrodeposited Gold Nanodendrites and Mercapto-propanioc Acid

Due to vital essence of medicine dosage monitoring within therapeutic range, a simple, rapid, high performance, sensitive and environmentally friendly electrochemical sensor was designed and used to diagnose low concentrations of famotidine, a histamine-2 blocker, at pharmaceutical products and biological fluids. In this work, a simple, fast response and efficient voltammetic sensor was designed using the functionalized dendrite-like gold nanostructures with 3-mercapto-propanioc acid (3-MPA/Au-DNSs). Electrochemical studies confirmed well the efficiency of the surface modified glassy carbon electrode (GCE) with 3-MPA/Au-DNSs on amplification of response signal in the presence of famotidine in an applicable linear concentration range of 3.0 × 10-7-1.0 × 10-5 M. The limit of detection was evaluated to be 3.33 × 10-8 M (for S/N = 3) under the optimum conditions. The modified GCE with 3-MPA/Au-DNSs was successfully applied in determination of famotidine in real samples such as human serum and pharmaceuticals with recoveries of 104.8% and 100.90%, respectively.