Comparison of Serum Levels of Vitamins E and C and Dietary Antioxidants Intakes between Patients with Inflammatory Bowel Disease and Healthy Subjects

Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammatory disease of unknown etiology. Nutrition has been proposed as an important fac- tor in etiology of IBD. The aim of this study was to compare dietary intake of antioxi-dants and serum levels of á -tocopherol and vi- tamin C in IBD patients with that of healthy subjects. Materials and Methods: Twenty-six IBD and twenty-eight sex and age matched healthy subjects were selected as the case and control groups from gastroenterology and other wards respectively, during the fall and winter of 2005. Subjects’ serum vitamin C and alpha-tocopherol levels were analyzed using the HPLC method. Semi-quantitative food frequency ques- tionnaires were completed by all subjects during interviews. Results: There was no significant difference in serum levels of vitamin C and á- tocopherol between the two study groups. Intakes of whole grain bread and fresh vegetables in healthy subjects were 2.5 and 1.5 times higher than those of patients, respectively (p 0.05). Al-though patients consumed fewer cups of tea dai-ly (p 0.05), no significant difference was seen in the intakes of other dietary antioxidant sources between the two groups. Conclusion: Results of this study indicated that although there was no significant difference between vitamin C and α- tocopherol serum levels in the both groups, dietary intake of the main antioxidant sources in IBD patients was lower than healthy matched subjects. More advanced studies with higher number of subjects are needed to explore the antioxidant status in such patients