SYNTHESIS, CHARACTERIZATION AND KINETIC STUDIES OF SOME OXAZEPINE AND OXAZEPANE DERIVATIVES

1,3-Bis(2-hydroxy-benzylidene)-Thiourea and 1,3-Bis-(dimethylaminobenzylidene)- Thiourea were prepared by condensation of Thiourea with one equivalent and two equivalent of substituted benzaldehyde. These Schiff-bases were reacted with one equivalent of Maleic , Succinic and Phthalic anhydride in absolute ethanol to give 7-membered heterocyclic ring system of 2-(2-Hydroxyphenyl)- 4,7-dioxo-4,7-dihydro-[1,3] oxazpine-3-carbothioic acid amide and 2-(4- Dimethylamino-phenyl)-4,7-dioxo-4,7-dihydro-[1,3]oxazepine-3-carbothioiacid amide , 1,3-Bis(2-hydroxy-benzylidene)-Thiourea and 1,3-Bis-(dimethylaminobenzylidene)- Thiourea were reacted with two equivalent of Maleic and Succinic anhydride in same solvent to give 2 (7-membered) heterocyclic ring system of 2-(2- hydroxy-phenyl)-3-[2-(2-hydroxy-phenyl)-4,7-dioxo-[1,3]oxazepine-3-carbothioyl]- 2,3-dihydro-[1,3]oxazepine-a,7-dione and 2-(4-Dimethylamino-phenyl)-3-[2-(4- dimethylamino-phenyl)-4,7-dioxo-[1,3]oxazepine-3- carbothioyl]-2,3-dihydro- [1,3]oxazepine-4,7-dione. The constants of reaction velocity for (Schiff-bases)with Maleic , Succinic and Phthalic anhydride were studied and showed that the reaction wsa first – order one .Some of thermodynamic characteristics were evaluated and showed differences among the prepared compounds . The final products were identified by their melting points, elemental analysis, IR, 1H NMR and UV-Visible spectra