Synthesis ,Characterization and biological activity study of new Schiff s bases containing 3,4-dimethyl maleimide moiety

A series of new Schiff s bases containing 3,4-dimethyl maleimide moiety have been synthesized via multisteps synthesis including reaction of 3,4-dimethyl maleic anhydride with aniline producing N-phenyl-3,4-dimethyl maleimide which react with chlorosulfonicacid producing 4-(N- 3,4- dimethyl maleimidyl )phenyl sulfonyl chloride which on amination with hydrazine hydrate yielded in turn 4- ( N-3 ,4 -dimethyl maleimidyl) phenyl sulfonyl hydrazine and this when condensed with various aromatic aldehydes and ketones afforded the desirable Schiff bases .Structures of the prepared compounds were confirmed by spectroscopic methods including FTIR, 1HNMR,C13NMR spectroscopy and C.H.N analysis.The synthesized Schiff s bases were screened for their antibacterial activity against three microorganisms:Staphylococcus aureus, Escherichia Coli, and Psedomonas aeruginosa. They were found to exhibit high antibacterial activity.