Title of article :
Synthesis of New Diazahomoadamantanone and Study the Reactivity of Carbonyl group
Author/Authors :
Shukkur, Ahmad H. University of Al-Anbar - College of Education for Pure Sciences, Iraq , Kuznetsov, A. I. Lomonosov Academy of Fine Chemical Engineering, Russia , Serova, T. M. Institute of Physiologically Active Substances - Russian Academy of Science, Russia
Abstract :
In this paper, new diazahomoadamantane was prepared by condensation of cyclic ketone (cyclododecanone) with 1,3,6,8-tetraazatricyclo[4.4.1.13,8]dodecane and acetic acid in 2-propanol gave new diazahomoadamantanone (13,16-diazatetracyclo-[9.6.1.11,13.111,16]eicosan-18-one) by Mannich,s reaction. Also were studied the reactivity of carbonyl group with various chemical agents like ( NaBH4 , H2N-NH2.H2O and NH2-OH.HCl). A simplified procedure was developed for the synthesis of 1,3,6,8-tetraazatricyclo [4.4.1.13,8]dodecane from condensation of ethane-1,2-diamine with paraform (Type A) in a very good yield. This new compound was characterized by FT-IR, Mass spectrum, 1H NMR and 13C NMR spectroscopy methods.
Keywords :
Mannich reaction , Ethane , 1 , 2 , diamine , Paraformaldehyde , yclododecanone , Diazahomoadamantanone.
Journal title :
Journal Of University Of Anbar For Pure Science
Journal title :
Journal Of University Of Anbar For Pure Science
