Title of article :
ANTITUMOUR-PROMOTING AND CYTOTOXIC CONSTITUENTS OF ETLINGERA ELATIOR
Author/Authors :
Habsah, M. University College of Science and Technology Malaysia (KUSTEM) - Faculty of Science and Technology - Department of Chemistry, Malaysia , Ali, AM Universiti Putra Malaysia - Faculty of Food Science and Biotechnology - Department of Biotechnology, Malaysia , Lajis, NH Universiti Putra Malaysia - Institute of Bioscience - Phytomedicinal Laboratory, Malaysia , Sukari, MA Universiti Putra Malaysia - Faculty of Science and Environmental Study - Department of Chemistry, Malaysia , Yap, YH Universiti Putra Malaysia - Faculty of Science and Environmental Study - Department of Chemistry, Malaysia , Kikuzaki, H Osaka City University - Faculty of Human Life Science - Department of Food and Nutrition, Japan , Nakatani, N Osaka City University - Faculty of Human Life Science - Department of Food and Nutrition, Japan
Abstract :
Phytochemical studies on rhizome of Etlingera elatior have resulted in the isolation of 1,7-bis(4-hydroxyphenyl)-2,4,6-heptatrienone (1), demethoxycurcumin (2), 1,7- bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (3), 16-hydroxylabda-8(17),11,13- trien-16,15-olide (4), stigmast-4-en-3-one (5), stigmast-4-ene-3,6-dione (6), stigmast- 4-en-6b-ol-3-one (7), 5alpha,8alpha-epidioxyergosta-6,22-dien-3beta-ol (8). 1 and 4 were new compounds. Compounds 5 and 7 displayed high antitumour-promoting activity. Ethyl acetate extract showed a very significant cytotoxic activity against CEM-SS and MCF-7 cell lines (4 µg/ml and 6.25 µg/ml respectively). The antitumour- promoting activity was determined by EBV-EA assay and cytotoxic activity was determined by MTT assay.
Keywords :
Etlingera elatior , antitumour , promoting , EBV , EA , cytotoxic , CEM , SS , MCF , 7
Journal title :
The Malaysian Journal Of Medical Sciences (MJMS)
Journal title :
The Malaysian Journal Of Medical Sciences (MJMS)
