Saccharomyces boulardii as effective probiotic against Salmonella typhimurium in Mice

This study was designed to investigate the protective role of Sacchromyces bouladii on intestinal section of mice infected with Salmonella typhimurium. Mice were divided into four groups. Acontrol group is uninfected with bacteria represent (negative control) , a second group was infected with bacteria S.typhimurium 0.1 ml (2.5 ×10^7 cfu/ ml) only represent (positive control) , the third group Induced mice received oral dose of S. boulardii 0.1ml (1×10^9 cfu/mL). Treated mice received S. boulardii (1×10^9 cfu/mL) orally for 7 days, followed by Salmonella infection. At the end of the experimental period the histological Results showed that administration of S. typhimurium alone resulted in a necrosis, degenerative changes and inflammatory cells infiltration in intestinal sections as compared with normal section taken from uninfected mice, while pretreatment with the S. boulardii ameliorate this effect.