Author/Authors :
Honar, N. shiraz university of medical sciences - Nemazee Hospital - Gastroenterohepatology Research Center, شيراز, ايران , Imanieh, M. H. shiraz university of medical sciences - Nemazee Hospital - Gastroenterohepatology Research Center, شيراز, ايران , Imanieh, M. H. shiraz university of medical sciences - Nemazee Hospital - Shiraz Transplant Research Center, شيراز, ايران , Dehghani, S. M. shiraz university of medical sciences - Nemazee Hospital - Gastroenterohepatology Research Center, شيراز, ايران , Dehghani, S. M. shiraz university of medical sciences - Nemazee Hospital - Shiraz Transplant Research Center, شيراز, ايران , Haghighat, M. shiraz university of medical sciences - Nemazee Hospital - Gastroenterohepatology Research Center, شيراز, ايران , Geramizadeh, B. shiraz university of medical sciences - Nemazee Hospital - Shiraz Transplant Research Center, شيراز, ايران , Yaghobi, R. shiraz university of medical sciences - Nemazee Hospital - Shiraz Transplant Research Center, شيراز, ايران , Alborzi, A. shiraz university of medical sciences - Nemazee Hospital - Clinical Microbiology Research Center, شيراز, ايران , Ziaeian, M. shiraz university of medical sciences - Nemazee Hospital - Clinical Microbiology Research Center, شيراز, ايران , Kazemi, K. shiraz university of medical sciences - Nemazee Hospital - Shiraz Transplant Research Center, شيراز, ايران , Nikeghbalian, S. shiraz university of medical sciences - Nemazee Hospital - Shiraz Transplant Research Center, شيراز, ايران , Bahador, A. shiraz university of medical sciences - Nemazee Hospital - Shiraz Transplant Research Center, شيراز, ايران , Salahi, H. shiraz university of medical sciences - Nemazee Hospital - Shiraz Transplant Research Center, شيراز, ايران , Malek Hosseini, S. A. shiraz university of medical sciences - Nemazee Hospital - Shiraz Transplant Research Center, شيراز, ايران
Abstract :
Background: Liver transplantation (LT) is a life-saving treatment for end-stage liver diseases (ESLD). Cytomegalovirus (CMV) infection is one of the important causes of morbidity after LT.Objective: To evaluate the incidence of late-onset (after 6 months of LT) CMV infection in pediatric recipients.Methods: A retrospective analysis was conducted to evaluate 50 pediatric patients who underwent LT for 8 years at the LT Unit of Nemazee Hospital affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. We retrospectively investigated episodes of CMV infection after 6 months of LT proven by CMV antigenemia test.Results: Three recipients (6%) developed late-onset CMV infection. These patients finally responded to ganciclovir.Conclusion: CMV infection is one of the most common post-LT viral infections that usually occurs in the first six months of LT. Our study shows that the incidence of late-onset CMV infection is relatively low, but it still remains a significant problem. Therefore, monitoring and management is crucial for improving the survival of children
