Author/Authors :
Rahman, Md. Mahbubur Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) - Department of Gastroenterology, Bangladesh , Azam, Md. Golam Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) - Dept of Gastroenterology, Bangladesh , Ali, Md. Nowshad Sir Salimullah Medical College Mitford Hospital - Department of Gastroenterology, Bangladesh , Mohsin, Mostafa Nur Sadar Hospital, Bangladesh , Jamal, Md. Shah 200 Bedded General Hospital, Bangladesh , Rahim, Muhammad Abdur Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) - Dept of Medicine, Bangladesh , Ahmed, Habib Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) - Directorate General of Health Services (DGHS), Bangladesh , Hoque, Md. Nazmul Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) - Dept of Gastroenterology, Bangladesh , Buiyan, Tareq Mahmud Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) - Dept of Gastroenterology, Bangladesh , Rahman, Md. Anisur Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) - Dept of Gastroenterology, Bangladesh
Abstract :
Objectives: Clinical evaluation and identification of aetiology of asymptomatic raised serum alanine aminotransferase (ALT) level in newly detected adult diabetic and impaired glucose tolerance (IGT) patients. Methods: In this cross-sectional study, newly detected adult diabetic and IGT patients having asymptomatic raised serum ALT level of 1.5 times of upper limit of normal were evaluated clinically and by laboratory tests. Results: Total number of patients was 120, which was 3.1% of all newly registered diabetic and IGT patients over the study period. Male were 74 and female 46. Diabetes mellitus (DM) was found in 93.3% cases and IGT in 6.7%. Mean age was 43.1 years, mean body weight was 64.5 kg and mean body mass index (BMI) was 25.5 kg/m2. Central (abdominal) obesity was found in 61.5% cases. Increased waist hip ratio was found in 86.3% cases. Hypertension and hepatomegaly were present in 35% and 5.8% cases respectively. Dyslipidaemia was found in 98.3% cases and 45% patients fulfilled criteria for metabolic syndrome. Regarding etiology, 76.7% cases had non-alcoholic fatty liver disease (NAFLD), 8.3% had HBsAg sero-positivity, 4.2% had anti-HCV seropositivity and 3.3% had both NAFLD and HBsAg seropositivity. In 7.5% cases no cause was found. Raised serum ALT level had a significant correlation with metabolic syndrome (p= 0.016) and increasing age (p= 0.008). Conclusion: Elevation of serum ALT is common in DM and IGT. NAFLD is the commonest cause followed by hepatitis B and C virus infection.
Keywords :
alanine aminotransferase , asymptomatic , diabetes mellitus , impaired glucose tolerance , non , alcoholic fatty liver disease
