Author/Authors :
Nlcknam, Mohamad Hossein tehran university of medical sciences tums - Faculty ofMedicine - Molecular Immunology Research Center, تهران, ايران , Mahmoud, Mahdi tehran university of medical sciences tums - Faculty ofMedicine - Molecular Immunology Research Center, تهران, ايران , Amirzargar, Ali Akbar tehran university of medical sciences tums - Faculty ofMedicine - Molecular Immunology Research Center, تهران, ايران , Ganjalikhani Hakemi, Mazdak isfahan university of medical sciences - Faculty ofMedicine - Immunology Department, اصفهان, ايران , Khosravi, Farideh tehran university of medical sciences tums - Faculty ofMedicine - Molecular Immunology Research Center, تهران, ايران , Jarnshidr, Ahmad Reza tehran university of medical sciences tums - Shariati Hospital, تهران, ايران , Amirkhanl, Aref Pasteur Iinstitute of Iran - Epidemiology Department, تهران, ايران , Ansartpour, Bita tehran university of medical sciences tums - Faculty ofMedicine - Molecular Immunology Research Center, تهران, ايران , Pourpak, Zahra tehran university of medical sciences tums - Immunology, Asthma and Allergy Research Institute, تهران, ايران , Moin, Mostafa tehran university of medical sciences tums - Immunology, Asthma and Allergy Research Institute, تهران, ايران , Nikbin, Behrooz tehran university of medical sciences tums - Faculty ofMedicine - Molecular Immunology Research Center, تهران, ايران
Abstract :
The human leukocyte antigen-B27 is one of the class I molecules of the major histocompatibility complex which is strongly associated with ankylosing spondylitis (AS). The strength of the disease association with B27 varies markedly among racial and ethnic populations. It is an allele family, which constitutes about 31 subtypes, with a considerable geographic and ethnic difference in distribution. It is important to know whether certain subtypes show any preferential association with AS. Because there is no report regarding HLA-B27 subtypes in Iranian patients with AS, the main purpose of the present study was to assess the frequency of subtypes of human leukocyte antigen (HLA)-B27 in patients with ankylosing spondylitis in Iranian population One hundred and nineteen AS patients (82 HLA-B27 positive and 37 HLA-B27 negative) were selected for this study. HLA-B27 positive patients were screened by polymerase chain reaction amplification with sequence-specific primers (pCR-SSP) for B*27 subtyping. The results of present study revealed that only two subtypes were detected in Iranian patients, including B*2705 (52 patients, 63.4%) and B*2702 (30 patients, 36.6%). Our resu lts showed a restricted number of HLA-B27 subtypes associated with AS in Iran and an elevated frequency of the B*2705 allele in these patients similar to other EuroCaucasoid (Aryan) groups in the world.
Keywords :
Ankylosing spondylitis , Human Leukocyte Antigen , HLA , B27 subtypes , Iran
