Author/Authors :
TABATABAEI, PARVIZ tehran university of medical sciences tums - Department ofInfectious Diseases ofChildren s Medical Center Hospital, تهران, ايران , AGHAMOHAMMADI, ASGHAR tehran university of medical sciences tums - Department ofAllergy and Clinical Immunology ofChildren s Medical Center Hospital, تهران, ايران , MAMAISHI, SETAREH tehran university of medical sciences tums - Department ofInfectious Diseases ofChildren s Medical Center Hospital, تهران, ايران , ISAEIAN, ANNA tehran university of medical sciences tums - Department ofAllergy and Clinical Immunology ofChildren s Medical Center Hospital, تهران, ايران , HEIDARI, GOLNAZ tehran university of medical sciences tums - Department ofAllergy and Clinical Immunology ofChildren s Medical Center Hospital, تهران, ايران , ABDOLLAHZADEH, SINA tehran university of medical sciences tums - Department ofAllergy and Clinical Immunology ofChildren s Medical Center Hospital, تهران, ايران , PIROUZI, PIROUZ tehran university of medical sciences tums - Department ofAllergy and Clinical Immunology ofChildren s Medical Center Hospital, تهران, ايران , REZAEI, NIMA tehran university of medical sciences tums - Department ofAllergy and Clinical Immunology ofChildren s Medical Center Hospital, تهران, ايران , HEIDARNZHAD, HASSAN tehran university of medical sciences tums - Department ofPneumology ofMasih Daneshvari Hospital, تهران, ايران , MIRSAEID GHAZI, BAHRAM shahid beheshti university of medical sciences - Department ofPediatrics, تهران, ايران , YAGANEH, MEHDI tehran university of medical sciences tums - Department ofAllergy and Clinical Immunology ofChildren s Medical Center Hospital, تهران, ايران , CHERAGHI, TAHER tehran university of medical sciences tums - Department ofAllergy and Clinical Immunology ofChildren s Medical Center Hospital, تهران, ايران , ABOLHASANI, HASAN tehran university of medical sciences tums - Department ofAllergy and Clinical Immunology ofChildren s Medical Center Hospital, تهران, ايران , SAGHAFI, SHIVA tehran university of medical sciences tums - Department ofAllergy and Clinical Immunology ofChildren s Medical Center Hospital, تهران, ايران , ALIZADEH, HOUMAN tehran university of medical sciences tums - Department ofRadiology ofChildren s Medical Center, تهران, ايران , ANARAKI, MOHAMMAD REZA tehran university of medical sciences tums - Department ofPneumology ofImam Khomeini Hospital, تهران, ايران
Abstract :
Bronchiectasis is a chronic debilitating condition characterized by abnormal dilated thickwalled bronchi. To investigate humoral immune function in bronchiectatic patients, this study was performed. Forty patients with established diagnosis of bronchiectasis, who were referred from two tertiary care pulmonology centers in Tehran, were investigated in this study. Immunoglobulin isotypes concentrations and IgG-subclasses were measured by nephelometry and enzymelinked immunosorbent assay (ELISA) methods, respectively. All patients received unconjugated pneumococcal vaccine, and blood samples were taken before and 21 days after vaccination. Specific antibodies against whole pneumococcal antigens were measured using the ELISA method. Fifteen (37.5%) out of 40 patients were diagnosed to have defects in antibody mediated immunity including 5 (12.5%) patients with immunoglobulin class deficiency (2 with common variable immunodeficiency and 3 with IgA deficiency), 3 (7.5%) with IgG subclass deficiency and 7 (17.5%) patients had Specific antibody deficiency (SAD) against polysaccharide antigen despite normal levels of serum immunoglobulins and IgG subclasses. Our study along with several other studies confirmed that all patients with bronchiectasis should undergo thorough immunological evaluation in order to identify the presence of the underlying immunologic defect. This evaluation should include serum immunoglobulins, IgG subclasses concentrations and also determination of serum antibodies against pneumococcal antigens. Early diagnosis and appropriate treatment will prevent the subsequent complications and improve quality of life of affected individuals.
