Author/Authors :
Shamsian, BS shahid beheshti university of medical sciences - Mofid children’s hospital, Pediatric Congenital Hematological Disorders Research Center, تهران, ايران , Arabi, N shahid beheshti university of medical sciences - Mofid children’s hospital, Pediatric Congenital Hematological Disorders Research Center, تهران, ايران , Kazemi Aghdam shahid beheshti university of medical sciences - Mofid children’s hospital - Department of pediatric pathology, تهران, ايران , Rouzrokh, M shahid beheshti university of medical sciences - Mofid children’s hospital - Department of pediatric surgery, تهران, ايران , Ghojehvand, N shahid beheshti university of medical sciences - Mofid children’s hospital - Department of pediatric radiology, تهران, ايران , Azma, R shahid beheshti university of medical sciences - Mofid children’s hospital - Department of pediatric radiology, تهران, ايران , Kaji Yazdi, M shahid beheshti university of medical sciences - Mofid children’s hospital, Pediatric Congenital Hematologic Disorders Research Center, تهران, ايران , Alavi, S shahid beheshti university of medical sciences - Mofid Children Hospital, Pediatric Congenital Hematological Disorders Research Center, تهران, ايران , Arzanian, MT shahid beheshti university of medical sciences - Mofid children’s hospital, Pediatric Congenital Hematologic Disorders Research Center, تهران, ايران
Abstract :
Rosai-Dorfman disease or sinus histiocytosis with massive lymphadenopathy is a rare disorder that typically manifests as lymphadenopathy and systemic symptoms whose etiology remains poorly elucidated. The diagnosis is based on immunohistochemistry. Its treatment is poorly defined but the prognosis is usually favorable. Here we report a 14 year old boy who presented with massive bilateral cervical lymphadenopathy. Histopathological examination demonstrated lymphophagocytosis (emperipolesis) consistent with a diagnosis of Rosai-Dorfman disease. The clinical and histological aspects of the disease are discussed as a rare cause of lymphadenopathy.
Keywords :
Rosai , Dorfman disease , emperipolesis , case , Iran
