Author/Authors :
boskabadi, hassan mashhad university of medical sciences - faculty of medicine - department of pediatrics, Mashhad, Iran , maamouri, gholamali mashhad university of medical sciences - faculty of medicine - department of pediatrics, Mashhad, Iran , zakerihamidi, maryam islamic azad university, tonekabon branch - school of medical sciences - department of midwifery, Tonekabon, Iran , bagheri, fatemeh islamic azad university, mashhad branch - school of medical sciences - department of nursing, Mashhad, Iran , mashkani, baratali mashhad university of medical sciences - bioinformatics research group, Mashhad, Iran , mafinejad, shahin north khorasan university of medical sciences - faculty of medicine - department of pediatrics, Bojnord, Iran , faramarzi, rahelah mashhad university of medical sciences - faculty of medicine - department of pediatrics, Mashhad, Iran , boskabadi, abbas mashhad university of medical sciences - faculty of medicine - department of pediatrics, Mashhad, Iran , khodashenas, ezzat mashhad university of medical sciences - faculty of medicine - department of pediatrics, Mashhad, Iran , heidari, elaheh mashhad university of medical sciences - faculty of medicine - department of pediatrics, Mashhad, Iran , rakhshanizadeh, forough mashhad university of medical sciences - faculty of medicine - department of pediatrics, Mashhad, Iran
Abstract :
Objective: Early diagnosis is has a crucial role in both prevention and treatment of asphyxia-related complications. The current study aimed to evaluate the prognostic value of interleukin-6 (IL-6) and hypoxic ischemic encephalopathy grade in the prediction of mortality and the developmental status of neonates affected by prenatal asphyxia. Materials Methods: This cohort study was conducted on 38 term asphyxiated infants at Ghaem hospital, Mashhad, Iran, from 2013 to 2017. The HIE grade and serum IL-6 levels were determined at the time of birth. The developmental status was evaluated using the Denver II test at the end of the two-year follow-up. Results: HIE grade 3 resulted in 83% mortality rate and developmental delay among all survivors. The mean IL-6 level was 2.7 ng/ml in the control group (not affected HIE), which increased up to 29, 175, and 136 ng/ml in those with HIE grades of 1, 2, and 3, respectively. According to the ROC curve analysis, the cut-off level of 24 pg/ ml could predict the developmental delay with sensitivity and specificity of 96 and 92%, respectively. Conclusion: The IL-6 level and HIE grade are potential prognostic biomarkers for the determination of mortality and morbidity in asphyxiated neonates.
Keywords :
Perinatal Asphyxia , Hypoxic Ischemic Encephalopathy , Interleukin , 6 (IL , 6) , Developmental delay.
