Role of Apolipoprotien-B in the Development of Hypertension in Postmenopausal Women

Background: The cardiovascular diseases are more common in postmenopausal women because of non-formation of estrogens. This leads to derangements in lipid profile and apolipoprotiens A 1 and B. It has been seen that Apo B. is more related to the development of hypertension in postmenopausal women while cholesterol and triglycerides are not considerably related to this metabolic state. Study Design: Case Series Study Place and Duration: The department of physiology PGMI Lahore, from August 2006 - October 2006 Materials and Methods: 75 Pakistani females were included in this study. Three groups each having 25 members were formed with the following names:Control Group-(age range 25-44 years),Experimental Group 1 (age range 46-60 years),Experimental Group 2 (age range 61-80) Their consent was taken and 10cc blood was withdrawn. Serum cholesterol, triglycerides and apo. B were measured Results: The comparisons of mean values of all the parameter were made between various groups and it was deduced that cholesterol and triglycerides were non significantly altered P 0.05while there was significant change noted in the mean values of Apo B, while making comparisons between various groups of the study. There were also noted significant changes in comparison of mean value of Systolic blood pressure and Diastolic blood pleasure in various Group of the study Conclusion: Menopause is accompanied by development of hypertension which is linked with the derangements in the concentration of Apo B, in addition to other risk factors, like cholestrol and triglycerides