Antibiotic Susceptibility Pattern of Bacterial Pathogens Causing Urinary Tract Infection in a Tertiary Care Hospital

Objective: To determine the distribution of bacterial uropathogens and their susceptibility to antibiotics in our setting. Study Design: A prospective descriptive study from February 2009 to September 2009. Setting: Department of Urology, Pakistan Institute of Medical Sciences Islamabad, Pakistan. Material and Methods: 100 patients with symptoms of urinary tract infection (UTI) and positive culture were included in study. 12 antibiotics were tested for sensitivity. Patients were divided in two groups. Group I patients were those who attended urology outpatient department, while group II were who admitted in urology ward. Results: Escherichia coli (E.coli) was the most common isolate in both groups (60% and 53% in Group I and II respectively). Klebsiella pneumonie was second common pathogen in Group I while Pseudomonas aeruginosa was second common pathogen in Group II. Antibiotic susceptibility analysis for E.coli, the most common pathogen in both groups was as follows: Amoxycillin (25% and 14%), Amoxycillin / Clavulanate (55% and 24%), Ciprofloxacin (63% and 24%), Levofloxacin (73% and 43%), Cefixime (70% and 33%), Cefotaxime (70% and 38%), Ceftriaxone (75% and 37%), Cefoperazone / Sulbactum (93% and 76%), Amikacin (88% and 67%), Imipenem (95% and 86%) and Pipracillin / Tazobactum (95% and 86%). Conclusion: E.coli is the commonest isolate both in outpatient and inpatient setting. UTI in hospitalized patients is more resistant to commonly used antibiotics. Susceptibility of uropathogens to flouroquinolones is decreasing in hospitalized patients but in outpatient susceptibility to flouroquinolone is reasonable.