Massive Retinal Gliosis: A Rare Entity

Massive retinal gliosis (MRG) is a benign disorder in which there is proliferation of glial cells. MRG may be associated with chronic inflammation, vascular disorders, trauma, glaucoma and congenital abnormalities. Here we describe a case of MRG in a 23 year old female. She presented with congenital microphthalmia of the left eye with loss of vision. Due to cosmetic reasons she underwent left enucleation. The specimen was received at our department for Histopathological evaluation. Upon histological examination the eye showed massive retinal gliosis and strong positivity for GFAP (Glial fibrillary acidic protein) protein on Immunohistochemistry application.