Author/Authors :
Azmandian, Jalal tehran university of medical sciences tums - Nephrology Research Center, تهران, ايران , Azmandian, Jalal kerman university of medical sciences - Physiology Research Center, كرمان, ايران , Azmandian, Jalal kerman university of medical sciences - Department of Nephrology, Urology and Renal Transplantation, كرمان, ايران , Mandegary, Ali kerman university of medical sciences - Physiology Research Center, كرمان, ايران , Mandegary, Ali kerman university of medical sciences - Faculty of Pharmacy - Department of Pharmacology and Toxicology, كرمان, ايران , Saber, Azadeh kerman university of medical sciences - Department of Nephrology, Urology and Renal Transplantation, كرمان, ايران , Torshabi, Maryam tehran university of medical sciences tums - Faculty of Pharmacy - Department of Pharmaceutical Biotechnology, تهران, ايران , Etminan, Abbas kerman university of medical sciences - Department of Nephrology, Urology and Renal Transplantation, كرمان, ايران , Etminan, Abbas kerman university of medical sciences - Physiology Research Center, كرمان, ايران , Ebadzadeh, Mohammad-Reza kerman university of medical sciences - Physiology Research Center, كرمان, ايران , Ebadzadeh, Mohammad-Reza kerman university of medical sciences - Department of Nephrology, Urology and Renal Transplantation, كرمان, ايران , Fazeli, Faramarz zahedan university of medical sciences - Department of Urology, زاهدان, ايران , Soleymani, Samaneh kerman university of medical sciences - Faculty of Pharmacy - Department of Pharmacology and Toxicology, كرمان, ايران , Taghipour, Atefeh kerman university of medical sciences - Faculty of Pharmacy - Department of Pharmacology and Toxicology, كرمان, ايران , Karimi, Mohammad-Ali kerman university of medical sciences - Faculty of Pharmacy - Department of Pharmacology and Toxicology, كرمان, ايران
Abstract :
Introduction. Chemokines and chemokine receptors have a pivotal role in immunity and inflammation. We aimed to evaluate their role in kidney transplant rejection. Materials and Methods. The association of chemokine (C-C motif) receptor 2 (CCR2)-V64I and CCR5-Δ32 gene polymorphisms with acute rejection (AR) and delayed graft function (DGF) were examined in 100 donor-recipient pairs. The CCR2-V64I and CCR5-Δ32 alleles were determined using polymerase chain reaction and polymerase chain reaction-restriction fragment length polymorphism, respectively. Results. No associations were found between donors or recipients’ CCR2-V64I and CCR5-Δ32 gene polymorphisms and AR or DGF. Of the characteristics of the donors, recipients, and transplantation, glomerulonephritis as a cause of kidney failure in the recipients was weakly associated with AR (relative risk, 6.1; 95% confidence interval, 0.8 to 46.0; P = .07). Transplantation of kidney from females to males was weakly associated with DGF (relative risk, 5.5; 95% confidence interval, 0.9 to 33.0; P = .06). There was a significant association between AR, but not DGF, and graft loss in the patients (relative risk, 28.6; 95% confidence interval, 1.7 to 487.0; P = .03). Conclusions. Our study failed to suggest CCR2-V64I or CCR5-Δ32 gene polymorphisms as risk factors for AR and DGF in kidney transplantation. Sex-matching between donors and recipients should be considered for living donor kidney transplantation.
