Author/Authors :
Gaafar, Ayman Basque Country University - Hospital de Basurto - Departments of Anatomic Pathology, Spain , Valentí, Carla Hospital de Zumarraga, Spain , Echevarria, Celina Hospital de Zumarraga, Spain , Laforga, Juan B. Hospital Marina Alta, Spain , López, José I. Basque Country University - Hospital de Basurto - Departments of Anatomic Pathology, Spain
Abstract :
The clinical and histological findings of four cases of renal mucinous tubular and spindle cell carcinoma (MTSCC) are reported. Two cases were incidentally discovered during the radiological study of other diseases, and the other two presented with haematuria. Radical nephrectomy was done in the four cases. All the tumours showed the typical histology and immunohistochemistry described in this newly recognised entity. The patients remain free of disease after 3, 8, 10 and 48 months of follow up. The literature related to the diagnosis of this tumour is thoroughly reviewed. Also, the proposed histopathogenetic theories for this tumour are also briefly commented on. The new 2004 WHO classification system of renal tumours is based on morphologic criteria and supported by common genetic findings.12 Among other rare entities, it includes a variant of renal carcinoma termed mucinous tubular and spindle cell carcinoma (MTSCC). This tumour type had been previously diagnosed as papillary renal carcinoma, metanephric adenoma, unclassified or sarcomatoid carcinoma,5,8,11,13 and seems to portend a favourable clinical outcome. We report the clinicopathological findings of four additional cases of this rare newly recognised tumour, highlighting its varied histological patterns and differential diagnosis. The cases were collected retrospectively from consultation of our archive in the last 3 years.
