Author/Authors :
Moghadami, M. shiraz university of medical sciences - Shiraz Medical School - Departments of Internal Medicine, شيراز, ايران , Masoumpoor, M. shiraz university of medical sciences - Shiraz Medical School - Departments of Internal Medicine, شيراز, ايران , Tabei, S. M. B. shiraz university of medical sciences - Shiraz Medical School - Departments of Internal Medicine, شيراز, ايران , Tabaei, S. M. H. shiraz university of medical sciences - Shiraz Medical School - Departments of Internal Medicine, شيراز, ايران , Sadeghi, H. shiraz university of medical sciences - Shiraz Medical School - Departments of Internal Medicine, شيراز, ايران , Gholami, K. shiraz university of medical sciences - Shiraz Medical School - Departments of Internal Medicine, شيراز, ايران , Lankarani, K. B. shiraz university of medical sciences - Shiraz Medical School - Departments of Internal Medicine, شيراز, ايران
Abstract :
Background: Methanol poisoning may result to death and permanent complications, sporadic cases of methanol poisoning are fairly rare and the largest experience are generally gained from managing methanol intoxication epidemics. The main metabolite of methanol is acid formic that is the prime metabolite responsible for toxic effects of methanol and since folate dependent systems are responsible for the oxidation of formi c acid to CO2 and water. It is belie ved that administration of folic acid enhances the metabolism of form ate. Though therapeutic effects of folic or folinic acid has never been fully tested in clinical trail s in human. Our objective was to evaluate therapeutic effect of folinic acid in methanol poisoned persons. Methods: In recent methanol poisoning epidemic due to bootleg Liquor consumption in Shiraz at 2004, Sixty-two patients have hospitalized. Folinic acid was admin istered to 19 patients and therapeuti c effe ct of folinic acid was studied. Results: There was no signi fi cant difference between two groups of patient s and number of decreased visual acuity , renal function, hospital stays and needs to bicarbonate therapy and hemodialysis. The only effect was decreasing acidosis in folate treated patients. Conclusion: Regardless of prior animal studies and case reports, with attention to our study limitation we didn t found significant protective ef fect of folinic acid infusion among methanol poisoning patients. The only effect was decreasing acidosis in folate received patients. Further studies in optimal situation is needed for definite judgment.
