Author/Authors :
Tagajdid, Mohamed Rida Mohamed V Souissi University - Mohamed V Military Teaching Hospital - Laboratory of Virology, Morocco , Doblali, Taoufik Mohamed V Souissi University - Mohamed V Military Teaching Hospital - Laboratory of Virology, Morocco , Elannaz, Hicham Mohamed V Souissi University - Mohamed V Military Teaching Hospital - Laboratory of Virology, Morocco , Hammi, Salaheddine Mohamed V Military Teaching Hospital - Department of Internal Medicine, Morocco , Belfequih, Bouchra Mohamed V Souissi University - Mohamed V Military Teaching Hospital - Laboratory of Virology, Morocco , Mrani, Saâd Mohamed V Souissi University - Mohamed V Military Teaching Hospital - Laboratory of Virology, Morocco
Abstract :
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse cutaneous reactions to drugs. We describe the case of a 19 year old patient with SJS/TEN overlap syndrome, who developed severe interstitial pneumonia after she had received antiepileptic drugs. A cytomegalovirus infection was diagnosed by Real Time Polymerase Chain Reaction (RTPCR) detection on Bronchoalveolar lavage. Based on observations on biological data, temporal relationship, and clinical features, it could be inferred that the reactivation of cytomegalovirus with viral replication can predispose a person to TEN-SJS. We discuss here, in the light of the current literature, the probable association between drug-induced SJS-TEN and fulminant reactivation of cytomegalovirus.
