Author/Authors :
Badruzzaman, Md. National Institute of Cardiovascular Diseases (NICVD) - Department of Cardiac Surgery, Bangladesh , Hossain, Aslam National Institute of Cardiovascular Diseases (NICVD) - Department of Cardiac Surgery, Bangladesh , Adhikary, Asit Baran National Institute of Cardiovascular Diseases (NICVD) - Department of Cardiac Surgery, Bangladesh , Quader, SA National Institute of Cardiovascular Diseases (NICVD) - Department of Cardiac Surgery, Bangladesh , Kamal, Sarwar National Institute of Cardiovascular Diseases (NICVD) - Department of Cardiac Surgery, Bangladesh , Saha, Sanjoy Kumar National Institute of Cardiovascular Diseases (NICVD) - Department of Cardiac Surgery, Bangladesh
Abstract :
Background: This prospective non-randomized clinical study was done to compare Off-pump and Onpumpmyocardial revascularization by Troponin I release in patients undergoing first elective coronaryartery bypass graft used to evaluate myocardial injury. Methods: One hundred an twenty patients werenon-randomly assigned to a Off-pump or On-pump myocardial revascularization group. CardiacTroponin I (CTnI) were measured in serial venous blood samples drawn preoperatively in both groups.In On-pump group after aortic unclamping at 12 and 24 hours and in Off-pump group after the lastdistal anastomosis at 12 and 24 hours. Results: The total amount of CTnI release were significantlyhigher in On-pump group than in Off-pump group. In On-pump group it was 2.1±1.9 (mean±SD)ng/ml vs in Off-pump group it was 1.0±1.7 (mean±SD) ng/ml at 12 hours and in On-pump group itwas 1.6±1.6 (mean±SD) ng/ml vs in Off-pump group it was .9±1.6 (mean±SD) ng/ml at 24 hours(P 0.0001 for the pattern). Conclusion: The lower release of CTnI in the Off-pump myocardialrevascularization group indicates that the arrested heart coronary revascularization group causes moredamage to the heart due to cardiopulmonary bypass than Off-pump myocardial revascularizationgroup.
