Abstract :
Health concerns over prophylactic abuse of herbal drugs are worrisome. However, histopathological perspectives are not so common. This study was designed to examine the histopathological pattern of the liver and kidney of white rats exposed to prophylactic abuse of Acafypha godseffiana crude leaf extract Thirty (30) albino rats of both sexes, with average mean weight of 199.82g were randomly selected into cages (A, B, C D) and a control cage (E) where n=6. Cages A-D received 200,400,600, and 600 mglg body weight of extract respectively. Commercially purchased drinking water and standard top feed were given ad libitum, tor 30 days. The animals were weighed before and after extract administration. Dullness and restlessness were observed and was marked on the high dose treated animals. The animals were sacrificed on day 31 by cervical dislocation. Grossing was done and was fixed in 10% buffered neutral fonnalin. Processed tissues at (3-5mm) were sectioned at 3- 5 microns. Grossly, all organs showed no apparent changes while histological findings were normal. This study revealed that prophylactic consumption of A. godseffiana leaf extract does not result in any histological changes in the organs (Liver and Kidney) studied. It can therefore be recommended for use.
