Author/Authors :
Naserpour Farivar, Taghi qazvin university of medical sciences - Cellular and Molecular Research Center Infectious Diseases, قزوين, ايران , Johari, Pouran qazvin university of medical sciences - Cellular and Molecular Research Center Infectious Diseases, قزوين, ايران , Johari, Pouran zahedan university of medical sciences - Tropical Medicine Research Center, زاهدان, ايران , Kouhpayeh, Hamid Reza zahedan university of medical sciences - Tropical Medicine Research Center, زاهدان, ايران , Kouhpayeh, Hamid Reza qazvin university of medical sciences - Cellular and Molecular Research Center Infectious Diseases, قزوين, ايران , Hashemi Shahri, Mohammad qazvin university of medical sciences - Cellular and Molecular Research Center Infectious Diseases, قزوين, ايران , Hashemi Shahri, Mohammad zahedan university of medical sciences - Tropical Medicine Research Center, زاهدان, ايران , Naderi, Mohammad zahedan university of medical sciences - Tropical Medicine Research Center, زاهدان, ايران , Naderi, Mohammad qazvin university of medical sciences - Cellular and Molecular Research Center Infectious Diseases, قزوين, ايران , Sharifi Moud, Batoul qazvin university of medical sciences - Cellular and Molecular Research Center Infectious Diseases, قزوين, ايران , Sharifi Moud, Batoul zahedan university of medical sciences - Tropical Medicine Research Center, زاهدان, ايران
Abstract :
Introduction: Tuberculous meningitis is a medical emergency that low sensitivity ofCSF smear staining and mycobacterial culture make its diagnosis difficult, so there isan urgent need for rapid, accurate and reliable laboratory test. The aim of this studywas comparing the sensitivity and specificity of CSF adenosine deaminase (ADA)level with Polymerase Chain Reaction (PCR) test in the diagnosis of tuberculousmeningitis (TBM).Methods and Materials: In the period between January 2007 and January 2008 wehad 49 patients with primary diagnosis of TBM in Bou-Ali University hospital. Aftercommitting and using the definite and probable TB as a golden standard, the finaldiagnosis for 29 of them was TBM.Results: Our study showed that the sensitivity and specificity of CSF-ADA level incomparison with PCR results in diagnosis of TBM with a 6.5 IU/L cut-off were 100%and 85% respectively. Our study showed that selecting a 6.5 IU/L cut-off with respectto the PCR results of the patients makes a reasonable sensitivity and specificity forCSF-ADA test in TBM diagnosis.Conclusion: Our study emphasized that CSF-ADA level measurement can be used asa good, rapid and reliable laboratory test for diagnosing tuberculous meningitis.
