Author/Authors :
Saeedi, Morteza mashhad university of medical sciences, مشهد, ايران , Etemadi, Mohammad Mehdi mashhad university of medical sciences, مشهد, ايران , Riasi, Hamid Reza birjand university of medical sciences, بيرجند, ايران , Ghandehari, Kavian mashhad university of medical sciences - School of Medicine - Department of Neurology, مشهد, ايران , Shoueibi, Ali mashhad university of medical sciences, مشهد, ايران , Boroumand, Amir Reza mashhad university of medical sciences, مشهد, ايران , Foroughipour, Mohsen mashhad university of medical sciences - Department of Neurology, مشهد, ايران
Abstract :
Introduction: HTLVI infection is an endemic disease of Khorasan state in Iran.Distribution of Multiple Sclerosis (MS) is different around the world.Methods and Materials: Data of MS patients were taken of MS registries forinterferon prescription in Razavi, Northern and Southern Khorasan provinces. MSwas diagnosed by neurologists based on McDonald criteria. Records from clinics andhospital based researches consitituted data of distribution of patients infected withHTLV1 with or without spastic paraparesis in Razavi and Southern Khorasanprovinces. Serologic tests of blood and/or CSF for HTLV1 and neuroexam byneurologists formed the methodology of HTLV1 investigation. Statistical centers ofhealth deputy of medical universities in the Khorasan provinces provided thepopulation data.Results: Total Prevalence of MS in Razavi, Northern and Southern Provinces ofKhorasan is 12.9, 8.7 and 5.3 cases per 100000 population respectively. Prevalenceof MS in female population of Razavi, Northern and Southern provinces of Khorasanis 19.9 , 11.2 and 8.3 cases per 100000 women respectively. Prevalence of MS inmale population of Razavi, Northern and Southern Provinces of Khorasan is 5.9, 6.2and 2.5 cases per 100000 men respectively. Total prevalence of HTLV1 infection inRazavi and Southern provinces of Khorasan is 2.4 and 0.5 cases per 100000population respectively. Prevalence of HTLV1 infection in female population ofRazavi and Southern provinces of Khorasan is 2.9 and 0.3 cases per 100000 womenrespectively. Prevalence of HTLV1 infection in male population of Razavi andSouthern provinces of Khorasan is 1.9 and 0.6 cases per 100000 men respectively.Spastic paraparesis was found in 46 % and 50% of cases infected with HTLV1 inRazavi and Southern provinces of Khorasan respectively.Conclusion: Frequency rate of MS is less than half in Southern province compared toRazavi province of Khorasan. HTLVI infection is 10 times more frequent in femalepopulation of Razavi compared to Southern province. There is considerabledifference in geographical distribution of MS and HTLV1 cases in Khorasanterritory.
