Effect of lysostaphin and crude extract of Salvia officinalis on local isolate Staphylococcus aureus I1 resistant to vancomycin

This study included determining the effect of lysostaphin enzyme, and crude extract of Salvia officinalis and the combination of the crude extract of Salvia officinalis with vancomycin, on growth of the S.aureus I1 isolate which is isolated from patients with osteomyelitis and resistant to vancomycin, the results showed that : water crude extract have many active compounds like glycosides, tannins, saponeins, flavonides, resins, volatiles oil, but no alkaloids were detected. The 15.25 mg/ml was the best concentration from crude extract of Salvia officinalis that inhibits growth of the isolate. The crude extract of Salvia officinalis increased in action of vancomycin in 260 times (in presence of 470 μg/ml) crude extract the concentration of lysostaphin 20μg/ml inhibits growth of S.aureus I1