Cytogenetic effect of lactobacillus acidophilus concentrated filtrate on albino mice bone marrow cells

This study deals with the cytogenetic effect of lactobacillus acidophilus concentrated filtrate on metaphase index of bone marrow cells in mice. Cyclophosphamide is a drug that is used primarily for treating several types of cancer. In order to work, cyclophosphamide first is converted by the liver into two chemicals, acrolein and phosphoramide. The results showed that lactobacillus acidophilus concentrated filtrate caused a significant increased in metaphase index in comparison with the negative control (distilled water) and positive controls (Cyclophosphamide) especially at high doses. The results of interaction study showed that pre- and posttreatment with lactobacillus acidophilus concentrated filtrate caused a significant increased in metaphase index of mice bone marrow cells.