Author/Authors :
Musso, Carlos G Hospital Italiano de Buenos Aires - Department of Nephrology, Argentina , Enz, Paula Hospital Italiano de Buenos Aires - Department of Dermatology, Argentina , Vidal, Flavia Hospital Italiano de Buenos Aires - Department of Toxicology, Argentina , Gelman, Rodolfo Hospital Italiano de Buenos Aires - Department of Endocrinology, Argentina , Lizarraga, Aldana Hospital Italiano de Buenos Aires - Department of Nephrology, Argentina , Giuseppe, Luis Di Hospital Italiano de Buenos Aires - Department of Farmacy, Argentina , Kowalczuk, Alicia Hospital Italiano de Buenos Aires - Department of Dermatology, Argentina , Garfi, Leonardo Hospital Italiano de Buenos Aires - Department of Farmacy, Argentina , Galimberti, Ricardo Hospital Italiano de Buenos Aires - Department of Dermatology, Argentina , Algranati, Luis Hospital Italiano de Buenos Aires - Department of Nephrology, Argentina
Abstract :
Calciphylaxis is an infrequent but severe entity found in chronic dialysis patients. Its clinical pattern consists of tissue ischemia with itchy and painful subcutaneous nodules and plaques, most often located on the abdomen, buttocks, thighs and/or legs. These injuries evolve to extensive superficial necrosis of the skin overlying the panniculitis, with ulceration, overinfection and consequent sepsis. Current treatment modalities used to counteract this pathology are not entirely effective. A new treatment reported for calciphylaxis, is the use of intravenous sodium thiosulfate. This inorganic salt is already used in the treatment of intoxication caused by cyanide, in patients with calcific nephrolithiasis and tumoral calcinosis, with very good and safe results. We herewith report a case of calciphylaxis that was cured using intravenous sodium thiosulphate treatment.
