Author/Authors :
Bouyahia, Olfa Children s Hospital of Tunis - Pediatric s Department, Tunisia , Khelifi, Ibtissem Children s Hospital of Tunis - Pediatric s Department, Tunisia , Gharsallah, Lamia Children s Hospital of Tunis - Pediatric s Department, Tunisia , Harzallah, Kais Military Hospital - Nephrology Department, Tunisia , Mazigh Mrad, Sonia Children s Hospital of Tunis - Pediatric s Department, Tunisia , Ghargah, Tahar Charles Nicole Hospital of Tunis - Pediatric s Department, Tunisia , Boukthir, Samir Children s Hospital of Tunis - Pediatric s Department, Tunisia , Gharbi Azza, Sammoud El Children s Hospital of Tunis - Pediatric s Department, Tunisia
Abstract :
Only few cases of nephrotic syndrome associated with Guillain-Barre Syndrome (GBS) have been reported in the adult and pediatric literature. A 3-year-old boy was initially admitted to our hospital following five days of progressive weakness of his extremities, fatigue, right leg pain and numbness. There was no past history of renal or neurological disease. Cerebrospinal fluid studies showed a protein level of 92 mg/dL and a white cell count of 1 per high-power field. The diagnosis of GBS was verified with a nerve conduction velocity test as well as. The GBS symptoms improved gradually on intravenous immunoglobulin. Three weeks later, he developed severe proteinuria and edema; laboratory investigation showed nephrotic syndrome which responded to steroid therapy. Renal biopsy showed minimal change glomerulonephritis. He remained free of proteinuria during his 20 months of follow-up.
