Studying some Cytotoxic Parameters of Aspartame (Diet sweet) on Mature Albino Male Mice

The present study was planned to evaluate some cytotoxic effect of aspartame intake troughdetermining the apoptosis cells from peripheral blood and sperm head abnormality from caudaepididymis. After one week of administration of various doses of asparatame (3.5,35,350 mg/kg) tomature albino male mice and distilled water treated group was served as control. The results werestatistically analyzed to compare the data of individual dose with that of the control, apoptotic andnecrotic cells as well as sperm head are determined. The results showed that induce apoptosis cellsin all concentrations (3.5,35,350 mg/kg) and necrotic cells in doses (35, 350 mg/kg) while lateapoptosis in doses (35, 3.5 mg/kg) on the other hand, asparatame is increased in sperm headabnormality in (350, 35 mg/kg) dose. According to these results, it was possible to conclude that aspartame have a cytotoxic risk. Therefore, it is necessary to be careful when using such materialsin food and beverages as a sweetener.