Author/Authors :
Upadhaya, Bala Krishna All India Institute of Medical Sciences - Department of Nephrology, India , Sharma, Alok All India Institute of Medical Sciences - Department of Pathology, India , Khaira, Ambar All India Institute of Medical Sciences - Department of Nephrology, India , Dinda, Amit K All India Institute of Medical Sciences - Department of Pathology, India , Agarwal, Sanjay K All India Institute of Medical Sciences - Department of Nephrology, India , Tiwari, Suresh C All India Institute of Medical Sciences - Department of Nephrology, India
Abstract :
Dengue virus infection can clinically manifest as dengue fever, dengue shock syndrome and dengue hemorrhagic fever. Acute kidney injury as a result of dengue virus infection can occur due to various reasons including hypotension, rhabdomyolysis, sepsis and rarely immune complex mediated glomerular injury. However, glomerulonephritis associated with IgA Nephropathy in dengue virus infection has not been reported previously. We report a case of 15year-old boy who was admitted with dengue fever and dialysis dependant acute kidney injury. Urine examination showed microscopic glomerular hematuria and proteinuria. Kidney biopsy showed mesangial proliferation with mesangial IgA dominant immune complex deposits and acute tubular necrosis. A repeated kidney biopsy 6 weeks after clinical recovery showed reversal of glomerular changes as well as resolution of mesangial IgA deposits.
