Author/Authors :
Iida, Shoichi Tokyo Women’s Medical University - School of Medicine - Department of Urology, Japan , Ishida, Hideki Tokyo Women’s Medical University - School of Medicine - Department of Urology, Japan , Miyamoto, Naoshi Tokyo Women’s Medical University - School of Medicine - Department of Urology, Japan , Shirakawa, Hiroki Tokyo Women’s Medical University - School of Medicine - Department of Urology, Japan , Shimizu, Tomokazu Tokyo Women’s Medical University - School of Medicine - Department of Urology, Japan , Setoguchi, Kiyoshi Tokyo Women’s Medical University - School of Medicine - Department of Urology, Japan , Toki, Daisuke Tokyo Women’s Medical University - School of Medicine - Department of Urology, Japan , Tanabe, Kazunari Tokyo Women’s Medical University - School of Medicine - Department of Urology, Japan
Abstract :
We present a kidney transplantation patient who developed rhabdomyolysis. The patient was initially immunosuppressed with tacrolimus,mycophenolate mofetil,steroids,and chimeric CD25 monoclonal antibody. He complained of severe precordial and appendicular pain on 25th day after the operation. The patient developed rhabdomyolysis manifested as a rise in serum creatine phosphkinase (CPK) and elevation of urinary myoglobulin at approximately the same time as his symptoms. Although he was switched from tacrolimus to cyclosporine (CYA),his muscle pain and levels of serum CPK did not improve. However,dividing the daily total amount of the calcinuerin inhibitors into more frequent doses in order to reach lower serum levels resolved the rhabdomyolysis. Therefore,we conclude that his rhabdomyolysis might be a dose-related problem of calcineurin inhibitor.
