Author/Authors :
Bouattar, Tarik Ibn Sina University Hospital - Unit of Nephrology, Dialysis and Renal Transplantation, Morocco , Kazmouhi, Laila Ibn Sina University Hospital - Unit of Nephrology, Dialysis and Renal Transplantation, Morocco , Alhamany, Zaitouna HER - CHU Ibn Sina - Laboratory of Pathologic Anatomy, Morocco , Beqqal, Kawtar Ibn Sina University Hospital - Unit of Dermatology, Morocco , Haffane, Laila Ibn Sina University Hospital - Unit of Nephrology, Dialysis and Renal Transplantation, Morocco , Houssaini, Tarik Sqalli Ibn Sina University Hospital - Unit of Nephrology, Dialysis and Renal Transplantation, Morocco , Rhou, Hakima Ibn Sina University Hospital - Unit of Nephrology, Dialysis and Renal Transplantation, Morocco , Benamar, Loubna Ibn Sina University Hospital - Unit of Nephrology, Dialysis and Renal Transplantation, Morocco , Senouci, Karima Ibn Sina University Hospital - Unit of Dermatology, Morocco , Bayahia, Rabia Ibn Sina University Hospital - Unit of Nephrology, Dialysis and Renal Transplantation, Morocco , Ouzeddoun, Naima Ibn Sina University Hospital - Unit of Nephrology, Dialysis and Renal Transplantation, Morocco
Abstract :
Kaposi s sarcoma (KS) is widely reported to develop after renal transplantation and is induced by activation of a latent human herpes virus 8. We report the clinical features and outcome of a 50-year-old woman who presented with KS 18 weeks after starting immunosuppressive therapy for vasculitis. She had positive-titer IgG antibody to human herpes virus 8. Cyclophosphamide pulses were interrupted,and prednisone was decreased gradually to 10 mg/day. Skin lesions showed important regression with stabilization of the general state and renal function. Eight months later,the patient presented with a diffuse cutaneous KS that required the discontinuation of steroids. Within 1 month,her general status and renal function deteriorated,and she died with a disseminated intravascular coagulation syndrome.
