Author/Authors :
Ngo, B. T. University of Cape Town - Groote Schuur Hospital, Medical Research Council, Liver Research Centre - Departments of Surgery and Medicine, Transplant Unit, South Africa , Pascoe, M. University of Cape Town - Groote Schuur Hospital, Medical Research Council, Liver Research Centre - Departments of Surgery and Medicine, Transplant Unit, South Africa , Kahn, Delawir University of Cape Town - Groote Schuur Hospital, Medical Research Council, Liver Research Centre - Departments of Surgery and Medicine, Transplant Unit, South Africa
Abstract :
We report two cases of drug interaction between rifampicin and sirolimus in renal trans-plant patients who were diagnosed with tuberculosis after transplantation and induction of immuno-suppressive therapy with sirolimus. The dosage of sirolimus had to be increased,in one case up to six-fold and in the second case up to five-fold,to maintain serum levels after starting the rifampicin. The two patients tolerated the treatment well,with no signs of tuberculosis and good renal function.
