Author/Authors :
Barbouch, Samia Charles Nicoles Hospital - Research Laboratory of Immunology, Tunisia , Cherif, Mejda Charles Nicoles Hospital - Department of Nephrology and Laboratory of Renal Pathology, Tunisia , Ounissi, Mondher Charles Nicoles Hospital - Research Laboratory of Immunology, Tunisia , Karoui, Cyrine Charles Nicoles Hospital - Department of Nephrology and Laboratory of Renal Pathology, Tunisia , Mzoughi, Sonia Charles Nicoles Hospital - Department of Nephrology and Laboratory of Renal Pathology, Tunisia , Ben Hamida, Fethi Charles Nicoles Hospital - Research Laboratory of Immunology, Tunisia , Abderrahim, Ezeddine Charles Nicoles Hospital - Research Laboratory of Immunology, Tunisia , Bozouita, Abdellatif Charles Nicoles Hospital - Department of Urology, Tunisia , Ben Abdalla, Taieb Charles Nicoles Hospital - Department of Nephrology and Laboratory of Renal Pathology, Tunisia , Kheder, Adel Charles Nicoles Hospital - Research Laboratory of Immunology, Tunisia
Abstract :
Urinary tract infection (UTI) is the most frequent infectious complication among renal transplant recipients and a frequent cause of bacteremia,sepsis and acute graft failure. To evaluate the incidence,risk factors,type of pathogens and long-term effect of UTIs on graft and patient survivals in our center,we performed a retrospective cohort study reviewing the medical records of patients who received a renal transplant at our center from June 1986 to December 2009,excluding patients who lost their grafts in the first month due to arterial or veins thrombosis and acute antibody-mediated rejection. We studied 393 kidney-transplanted recipients; at least one UTI occurred in 221 (53.69%) patients during the follow-up period. The most frequent pathogens isolated in urine culture were Escherichia coli (n = 39,18.4%) and Klebsiella pneumonia (n = 31,14.6%). When patients with UTIs were compared with those without UTIs,female gender and use of mycophenolate mofetil or azathioprine seemed to be risk factors for UTIs on univariate analysis. However,female gender was the only independent risk factor on multivariate analysis RR = 1.964 (1.202-3.207),P = 0.007. This study confirmed that UTIs remain a major problem in renal transplant recipients,and female gender was the only independent risk factor.
