Author/Authors :
Gumber, M. R. Institute of Kidney Diseases and Research Center-Institute of Transplantation Sciences (IKDRC-ITS), Civil Hospital Campus - Department of Nephrology and Clinical Transplantation, India , Jain, S. H. Institute of Kidney Diseases and Research Center-Institute of Transplantation Sciences (IKDRC-ITS), Civil Hospital Campus - Department of Nephrology and Clinical Transplantation, India , Kute, V. B. Institute of Kidney Diseases and Research Center-Institute of Transplantation Sciences (IKDRC-ITS), Civil Hospital Campus - Department of Nephrology and Clinical Transplantation, India , Shah, P. R. Institute of Kidney Diseases and Research Center-Institute of Transplantation Sciences (IKDRC-ITS), Civil Hospital Campus - Department of Nephrology and Clinical Transplantation, India , Patel, H. V. Institute of Kidney Diseases and Research Center-Institute of Transplantation Sciences (IKDRC-ITS), Civil Hospital Campus - Department of Nephrology and Clinical Transplantation, India , Vanikar, A. V. Institute of Kidney Diseases and Research Center-Institute of Transplantation Sciences (IKDRC-ITS), Civil Hospital Campus - Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, India , Modi, P. R. Institute of Kidney Diseases and Research Center-Institute of Transplantation Sciences (IKDRC-ITS), Civil Hospital Campus - Department of Urology and Transplantation, India , Trivedi, H. L. Institute of Kidney Diseases and Research Center-Institute of Transplantation Sciences (IKDRC-ITS), Civil Hospital Campus - Department of Nephrology and Clinical Transplantation, India
Abstract :
Nowadays,a repeat transplantation is considered to confer a better survival advantage to patients over dialysis. The cost-effectiveness of transplantation for end-stage renal disease patients shows benefits over dialysis even for re-transplanted patients. This retrospective single center ten-year study was undertaken to evaluate patient/graft survival,function vis-à-vis serum creatinine (SCr) and rejection episodes in 62 re-transplanted patients. Sixty-two patients underwent a second renal transplant (24 living related,38 deceased donors) at our center between 2000 to 2009. The mean recipient age was 41.9 ± 12.27 years. Fifty-three recipients were male and nine recipients were female. Recipients had negative acceptable lymphocyte cross-matching using anti-human globulin complement-dependent cytotoxicity tests and flow cytometric cross-match before transplant. All recipients except those who were hepatitis C virus or hepatitis B surface antigen positive received single-dose rabbit-anti-thymocyte globulin induction and steroids,calcineurin inhibitor ± mycophenolate mofetil/azathioprine for maintenance immunosuppression. Of the 62 patients,38 patients received kidneys from deceased donors and 24 patients received kidneys from live donors. Over the mean follow-up of 4.03 ± 2.93 years,the 1-year,5-year and 10-year patient survival rates were 85.33%,66.7% and 66.7%,respectively,and the graft survival rates were 96.7%,79.7% and 79.7%,respectively. The acute rejection rates were 17.6%,with a mean SCr of 1.92 ± 0.5 mg/dL. There was unexplained interstitial fibrosis with tubular atrophy in 11.2% patients (n = 7),all leading to graft loss eventually. Overall,25% (n = 16) of the patients were lost,mainly to infectious complications. Re-transplantation has acceptable graft and patient survival over a ten-year follow-up period and should be encouraged for better quality of life as compared with dialysis.
