Title of article
Performance of QuantiFERON TB Gold test in detecting latent tuberculosis infection in brain-dead organ donors in Iran: a brief report
Author/Authors
Tabarsi, Payam shahid beheshti university of medical sciences - National Research Institute of Tuberculosis and Lung Disease, Clinical Tuberculosis and Epidemiology Research Center, Mycobacteriology Research Center, تهران, ايران , Yousefzadeh, Amir shahid beheshti university of medical sciences - National Research Institute of Tuberculosis and Lung Disease, Clinical Tuberculosis and Epidemiology Research Center, تهران, ايران , Najafizadeh, Katayoun shahid beheshti university of medical sciences - Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Disease, تهران, ايران , Droudinia, Atousa shahid beheshti university of medical sciences - National Research Institute of Tuberculosis and Lung Disease, Clinical Tuberculosis and Epidemiology Research Center, تهران, ايران , Bayati, Rouzbeh shahid beheshti university of medical sciences - National Research Institute of Tuberculosis and Lung Disease, Clinical Tuberculosis and Epidemiology Research Center, تهران, ايران , Marjani, Majid shahid beheshti university of medical sciences - National Research Institute of Tuberculosis and Lung Disease, Clinical Tuberculosis and Epidemiology Research Center, تهران, ايران , Shafaghi, Shadi shahid beheshti university of medical sciences - Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Disease, تهران, ايران , Farokhzad, Banafsheh shahid beheshti university of medical sciences - National Research Institute of Tuberculosis and Lung Disease, Clinical Tuberculosis and Epidemiology Research Center, تهران, ايران , Javanmard, Pedram shahid beheshti university of medical sciences - National Research Institute of Tuberculosis and Lung Disease, Clinical Tuberculosis and Epidemiology Research Center, تهران, ايران , Velayati, Ali Akbar shahid beheshti university of medical sciences - National Research Institute of Tuberculosis and Lung Disease, Clinical Tuberculosis and Epidemiology Research Center, Mycobacteriology Research Center, تهران, ايران
From page
1240
To page
1243
Abstract
With regard to the significant morbidity and mortality due to tuberculosis in lung transplant recipients,the identification of brain-dead organ donors with latent tuberculosis by use of the QuantiFERON TB Gold (QFT-G) test may be of help to reduce the risk of TB reactivation and mortality in lung recipients. This study was conducted in the National Research Institute of Tuber-culosis and Lung Diseases (NRITLD) in Iran,from January to March 2013. A total of 38 conse-cutive brain-dead donors,not currently infected with active tuberculosis,were recruited. The medi-cal records of all the study enrollees were reviewed. A whole-blood IFN- release assay (IGRA) in reaction to early secreted antigenic target 6 (ESAT-6),culture filtrate protein 10 (CFP-10),and TB7.7 antigens,was performed and the released Interferon- was measured via enzyme-linked immunosorbent assay (ELISA). The data was analyzed with QFT-G software which was provided by the company. The demographic,characteristics and other variables were entered into SPSS version 11.5. The QFT-G test results of three donors (7.9%) turned out to be positive,negative for 24 donors (63.1%),and indeterminate for 11 cases (28.9%). Our study revealed the potential advantages of QFT-G in lowering the incidence of donor-derived post-transplant tuberculosis among lung recipients. However,a high rate of indeterminate results restricted the performance of QFT-G in this study.
Journal title
Saudi Journal of Kidney Diseases and Transplantation
Journal title
Saudi Journal of Kidney Diseases and Transplantation
Record number
2677711
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