Author/Authors :
Tabarsi, Payam shahid beheshti university of medical sciences - National Research Institute of Tuberculosis and Lung Disease, Clinical Tuberculosis and Epidemiology Research Center, Mycobacteriology Research Center, تهران, ايران , Yousefzadeh, Amir shahid beheshti university of medical sciences - National Research Institute of Tuberculosis and Lung Disease, Clinical Tuberculosis and Epidemiology Research Center, تهران, ايران , Najafizadeh, Katayoun shahid beheshti university of medical sciences - Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Disease, تهران, ايران , Droudinia, Atousa shahid beheshti university of medical sciences - National Research Institute of Tuberculosis and Lung Disease, Clinical Tuberculosis and Epidemiology Research Center, تهران, ايران , Bayati, Rouzbeh shahid beheshti university of medical sciences - National Research Institute of Tuberculosis and Lung Disease, Clinical Tuberculosis and Epidemiology Research Center, تهران, ايران , Marjani, Majid shahid beheshti university of medical sciences - National Research Institute of Tuberculosis and Lung Disease, Clinical Tuberculosis and Epidemiology Research Center, تهران, ايران , Shafaghi, Shadi shahid beheshti university of medical sciences - Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Disease, تهران, ايران , Farokhzad, Banafsheh shahid beheshti university of medical sciences - National Research Institute of Tuberculosis and Lung Disease, Clinical Tuberculosis and Epidemiology Research Center, تهران, ايران , Javanmard, Pedram shahid beheshti university of medical sciences - National Research Institute of Tuberculosis and Lung Disease, Clinical Tuberculosis and Epidemiology Research Center, تهران, ايران , Velayati, Ali Akbar shahid beheshti university of medical sciences - National Research Institute of Tuberculosis and Lung Disease, Clinical Tuberculosis and Epidemiology Research Center, Mycobacteriology Research Center, تهران, ايران
Abstract :
With regard to the significant morbidity and mortality due to tuberculosis in lung transplant recipients,the identification of brain-dead organ donors with latent tuberculosis by use of the QuantiFERON TB Gold (QFT-G) test may be of help to reduce the risk of TB reactivation and mortality in lung recipients. This study was conducted in the National Research Institute of Tuber-culosis and Lung Diseases (NRITLD) in Iran,from January to March 2013. A total of 38 conse-cutive brain-dead donors,not currently infected with active tuberculosis,were recruited. The medi-cal records of all the study enrollees were reviewed. A whole-blood IFN- release assay (IGRA) in reaction to early secreted antigenic target 6 (ESAT-6),culture filtrate protein 10 (CFP-10),and TB7.7 antigens,was performed and the released Interferon- was measured via enzyme-linked immunosorbent assay (ELISA). The data was analyzed with QFT-G software which was provided by the company. The demographic,characteristics and other variables were entered into SPSS version 11.5. The QFT-G test results of three donors (7.9%) turned out to be positive,negative for 24 donors (63.1%),and indeterminate for 11 cases (28.9%). Our study revealed the potential advantages of QFT-G in lowering the incidence of donor-derived post-transplant tuberculosis among lung recipients. However,a high rate of indeterminate results restricted the performance of QFT-G in this study.
