Author/Authors :
Wang, Hui Guangxi Key Laboratory of Metabolic Diseases Research - 181st Hospital - Central Laboratory, China , Sui, Weiguo Guangxi Key Laboratory of Metabolic Diseases Research - 181st Hospital - Central Laboratory, China , Xue, Wen Guangxi Key Laboratory of Metabolic Diseases Research - 181st Hospital - Central Laboratory, China , Wu, Junyong Guangxi Key Laboratory of Metabolic Diseases Research - 181st Hospital - Central Laboratory, China , Chen, Jiejing Guangxi Key Laboratory of Metabolic Diseases Research - 181st Hospital - Central Laboratory, China , Dai, Yong Guangxi Key Laboratory of Metabolic Diseases Research - 181st Hospital - Central Laboratory, China , Dai, Yong Jinan University - Second Clinical Medical College, Shenzhen People’s Hospital, Clinical Medical Research Center, China
Abstract :
Immunoglobulin A nephropathy (IgAN) is a complex trait regulated by the interaction among multiple physiologic regulatory systems and probably involving numerous genes,which leads to inconsistent findings in genetic studies. One possibility of failure to replicate some single-locus results is that the underlying genetics of IgAN nephropathy is based on multiple genes with minor effects. To learn the association between 23 single nucleotide polymorphisms (SNPs) in 14 genes predisposing to chronic glomerular diseases and IgAN in Han males,the 23 SNPs genotypes of 21 Han males were detected and analyzed with a BaiO gene chip,and their associations were analyzed with univariate analysis and multiple linear regression analysis. Analysis showed that CTLA4 rs231726 and CR2 rs1048971 revealed a significant association with IgAN. These findings support the multi-gene nature of the etiology of IgAN and propose a potential gene-gene interactive model for future studies.
