Title of article :
STUDY OF INTERACTION OF DRUGS WITH BODY-ALIKE MACROMOLECULE (POLYVINYLPYRROLIDONE) BY ULTRA VIOLET SPECTROSCOPIC METHOD
Author/Authors :
SAEED, AKHTAR University of Peshawar - National Center of Excellence in Physical Chemistry, Pakistan , UR RAHMAN, AMIN University of Peshawar - National Center of Excellence in Physical Chemistry, Pakistan , UL ISLAM, NAZAR University of Peshawar - Department of Pharmacy, Pakistan , SAEED, MOHAMMAD IIUM - Kulliyyah of Pharmacy - Department of Pharmaceutical Chemistry, Malaysia , ASHHAD HALIMI, S. M. Government Medicines Co-ordination Cell, at L. R. Hospital, Pakistan
Abstract :
UV-visible spectrophotometric technique was used to study the interaction of polyvinylpyrrolidone (PVP) with co-solutes: phenol, benzoic acid, sodium benzoate, salicylic acid and acetyl salicylic acid in aqueous medium. Changes in the absorption spectra of the co-solutes were observed in the presence of PVP from 200 to 210 nm. The changes were attributed to interaction of PVP molecules with the co-solute molecules. As the concentration of the co-solute increased, a red shift in the bands was observed indicating an increase in interaction between PVP and the co-solute
Keywords :
Polyvinylpyrrolidone , Phenol , Benzoic acid , Acetyl salicylic acid , UV , visible spectrometry
Journal title :
Malaysian Journal of Pharmaceutical Sciences
Journal title :
Malaysian Journal of Pharmaceutical Sciences
