Studies on the preparation and characterisation of β-cyclodextrin-aceclofenac inclusion complexes

Aceclofenac/-cyclodextrin (Ace/-CD) dispersions were prepared to study the influence of -CD on the solubility and dissolution rate of this poorly soluble drug. Phase-solubility profile indicated that the solubility of aceclofenac was significantly increased in the presence of -CD and was classified as AL-type, indicating the 1:1 stoichiometric inclusion complexes. Physical characterisation of the prepared systems was carried out by differential scanning calorimetry (DSC), X-ray diffractometry (XRD) and IR studies. Solid state characterisation of the drug in the -CD binary system using XRD, FTIR and DSC revealed distinct loss of drug crystallinity in the formulation, ostensibly accounting for enhancement of dissolution rate