Author/Authors :
chen, shuqiu southeast university - zhongda hospital, urological institute, NanJing, china , jiang, guiya southeast university - medical school, NanJing, China , liu, ning southeast university - zhongda hospital, urological institute, NanJing, China , jiang, hua southeast university - zhongda hospital, urological institute, NanJing, China , zhang, lijie southeast university - zhongda hospital, urological institute, NanJing, China , sun, chao southeast university - zhongda hospital, urological institute, NanJing, China , xu, bin southeast university - zhongda hospital, urological institute, NanJing, China , zhang, xiaowen southeast university - zhongda hospital, urological institute, NanJing, China , yang, yu southeast university - zhongda hospital, urological institute, NanJing, China , liu, jing southeast university - zhongda hospital, urological institute, NanJing, China , zhu, weidong southeast university - zhongda hospital, urological institute, NanJing, China , chen, ming southeast university - zhongda hospital, urological institute, NanJing, China
Abstract :
Purpose: We discuss the safety and perioperative outcomes of a 2-week interval between prostate biopsy and laparoscopic radical prostatectomy (LRP). Materials and Methods: We retrospectively reviewed the medical records of 182 patients with prostate cancer (PCa) who underwent transperitoneal LRP 2 weeks after prostate biopsy between 2012 and 2015. We evaluated the following perioperative outcomes: operative time, estimated blood loss (EBL), infection, conversion to open surgery, positive surgery margins (PSM), and complications. We also reviewed studies discussing a shorter interval between biopsy and LRP in peer-reviewed publications. Results: The mean operative time and EBL were 100.2 min and 82.2 ml, respectively. There were no rectal injuries or conversions to open surgery, totally 19 (10.4%) patients experienced complications (Clavien- Dindo Grade I and II): fever occurred in six patients (3.3%), urinary leak in four (2.2%), incomplete paralytic ileus in four (2.2%), deep vein thrombosis in two (1.1%), and postoperative anemia in four. The average bedrest time after surgery was 2.5 days. PSM was detected in twenty-one patients (11.5%) . 167 patients (91.7%) recovered continence. Follow-up ranged from 13-37 months, the biochemical recurrence (BCR) rate was 10.4% (19/182).The seven peer-reviewed studies we reviewed that a shorter interval was safe and did not influence surgical outcomes. Conclusion: Our study shows that a 2-week interval between biopsy and LRP is safe and does not negatively affect surgical outcomes.
