Author/Authors :
Ramachandran, S. C. L. Baid Metha College of Pharmacy - Department of PharmaceuticaI Chemistry, India , Nalini, C. N. C. L. Baid Metha College of Pharmacy - Department of PharmaceuticaI Chemistry, India , Girija, C. R. SSMRV College - Department of Chemistry, India , Begum, Noor Shahina Bangalore University, Central College Campus - Department of Studies in Chemistry, India
Abstract :
Thiohydantoins have been proven to have anticonvulsant and antidepressant activity. Some derivatives of thiohydantoin containing both aryl group and benzylidene nucleus were synthesised and their anticonvulsant activity were investigated by pentylenetetrazole induced convulsions. It was found that the activity of Compound C was found to be significant when compared to that of the other three synthesized thiohydantoin compounds. Clonazepam is a marketed potent anticonvulsant drug. Compound C was compared with the clonazepam drug (0.2µg/10g).
