Author/Authors :
Cosan, Didem Eskisehir Osmangazi University - Medical Faculty, Turkey , Basaran, Ayse Eskisehir Osmangazi University - Medical Faculty, Turkey , Degirmenei, Irfan Eskisehir Osmangazi University - Medical Faculty, Turkey , Gunes, Hasan V. Eskisehir Osmangazi University - Medical Faculty, Turkey , Aral, Erine Eskisehir Osmangazi University - Medical Faculty, Turkey
Abstract :
Objectives: To observe the effects of paclitaxel on rats that received benzoapyrene.Methods: In this study, 45 male Sprague-Dawley rats aged 2-month-old were used, which were housed at the Medical Biology Department of Eskisehir Osmangazi University, Eskisehir, Turkey in 2006. Urine, blood, liver, and kidney tissue samples of Sprague Dawley rats treated with benzoapyrene and paclitaxel were examined in our study. Biochemical data were evaluated on urine and blood samples, and liver and kidney tissue samples were investigated by light microscopy.Results: Superoxide dismutase, catalase activities, and malondialdehyde values in the group which received benzoapyrene were significantly different than the control, and most of these parameters came close to control values in the group that received paclitaxel following benzoapyrene application. Histological appearances of the samples of all rats also supported the biochemical results.Conclusion: The present study indicated that liver and kidney structures damaged by benzoapyrene may be restored by paclitaxel.
