Author/Authors :
Saeidnia, Mohammadreza Department of Hematology - School of Paramedical - Shiraz University of Medical Sciences, Shiraz, Iran , Nam Avar Jahromi, Faride Department of Hematology - School of Paramedical - Shiraz University of Medical Sciences, Shiraz, Iran , Vaziee, Elnaz Department of Hematology - School of Paramedical - Shiraz University of Medical Sciences, Shiraz, Iran , Dehghani, Hossein Department of Hematology - School of Paramedical - Shiraz University of Medical Sciences, Shiraz, Iran , Mahmoodzade, Amir Medical Biology Research Center - Health Technology Institute - Kermanshah University of Medical Sciences, Kermanshah, Iran , Tamaddon, Gholam Hossein Diagnostic Laboratory Sciences and Technology Research Center - School of Paramedical Sciences - Shiraz University of Medical Sciences, Shiraz, Iran
Abstract :
Thrombotic Thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathic disease, associated with thrombocytopenia and hemolytic anemia. It is caused by an enzymatic dysfunction responsible in cleavage of blood clotting factors. In this study we have tried to review the available approaches in diagnoses of the disease as well as treatment strategies. Based on the what the current review has provided, treatment policy depends on accurate diagnosis, it seems that developing a diagnostic and treatment guide for this disease is currently essential. Also, it’s necessary to study genetic types of TTP with more details because, hopefully, new techniques of gene therapy open a window to more stable treatments.
