Title of article :
Analysis of Human Papillomavirus and Herpes Simplex Virus Genus -2 from Patients with Cervical Cancer in Isfahan, Iran
Author/Authors :
Shanehsazzadeh, Mehrnaz Academic Center for Education and Research - Zist Partak Institute - Department of Medicinal Biology, ايران , Sharifi-Rad, Javad zabol university of medical sciences - Faculty of Pharmacy, Zabol Medicinal Plants Research Center - Department of Pharmacognosy, ايران , Behbahani, Mandana Academic Center for Education and Research - Zist Partak Institute - Department of Medicinal Biology, ايران , Pourazar, Abbasali Academic Center for Education and Research - Zist Partak Institute - Department of Medicinal Biology, ايران
Abstract :
Background: Although cervical uterine cancer is a second form of cancer among women, but it occupies fifth form among all cancer types. Methods: In the present study, human papillomavirus (HPV) and herpes simplex virus 2 (HSV-2) in cervical cancer patients by using real time polymerase chain reaction (PCR) technique and the relation between their viral loads were investigated. 156 cervical carcinoma tissues were collected from married women in health centers in Isfahan, Iran. Results: The results showed that among 156 specimens, 58.97%, 45.51% and 7.05% were positivefor HPV DNA, HPV-16 and HPV-18 respectively. Only in 2.3% specimens, HSV-2 and HPV-16 were positively detected where viral load HSV-2 in conjunction with HSV-16 dramatically increased. Conclusion: Thus the present study not only confirmed that viral load of HPV-16 is more than other HPV types, but also in possible conjunction with HSV-2, both rates will significantly increase.
Keywords :
HPV , HPV16 , 18 , cervical cancer , HSV , 2 , real time PCR
Journal title :
Materia Socio Medica
Journal title :
Materia Socio Medica
