Author/Authors :
Ahmed, Qasem Anass Zagazig University - Faculty of Medicine - Internal Medicine Department, Egypt , El Sayed, Farag Salama Zagazig University - Faculty of Medicine - Internal Medicine Department, Egypt , Emad, Hamed Zagazig University - Faculty of Medicine - Internal Medicine Department, Egypt , Mohamed, Emara Zagazig University - Faculty of Medicine - Tropical Medicine Department, Egypt , Ahmed, Bihery Zagazig University - Faculty of Medicine - Tropical Medicine Department, Egypt , Heba, Pasha Zagazig University - Faculty of Medicine - Medical Biochemistry Department, Egypt
Abstract :
Background and aim: Acute kidney injury is a common complication in cirrhotic patients. Serum creatinine is a poor biomarker for detection of renal impairment in cirrhotic patients. The aim of this study was to evaluate Urinary Neutrophils Gelatinase-Associated Lipocalin (NGAL) and Urinary interleukin-18 (IL-18) as early biomarkers of acute kidney injury in cirrhotic patients. Patients and methods: 160 cirrhotic patients was enrolled in this study divided into 3 main groups according to presence or absence of ascites and renal impairment. Results: Significant elevation of both Urinary NGAL and Urinary IL-18 in cirrhotic patients with renal impairment especially in patients with Acute tubular necrosis (ATN) was observed. AUROC was (0.909) with (sensitivity 95.5 %, specificity 76.1) for Urinary NGAL and AUROC was (0.975), with (sensitivity 95.5 %, specificity 91.3 %) for Urinary IL-18. Conclusion: both Urinary NGAL and Urinary IL-18 can act as urinary biomarkers of acute kidney injury in cirrhotic patient.
Keywords :
Keywords: Cirrhosis , Acute kidney injury , NGAL , IL , 18 , Hepatorenal syndrome.
